What is 5-MeO-DMT?
5-MeO-DMT or O-methyl-bufotenin is a psychedelic of the tryptamine class, 5-MeO-DMT Crystalline. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado River toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America.
5 MeO DMT stands for 5-Methoxy-N,N-Dimethyltryptamine. In comparison to DMT, it is found in a much smaller number of plant species, and some animals, including the Colorado River toad (bufo alvarius).
Both substances can be extracted and consumed for their psychoactive effects. So far, research suggests that DMT could be helpful for treating depression, anxiety, substance abuse disorders, and post-traumatic stress disorder (PTSD).
Effects 5-MeO-DMT Crystalline
Depending on whether smoked or insufflated, total duration of experience can last between 10 minutes for the former, or up to 2 hours for the latter. Effects vary and can range from radical perspective shifting and perception of new insights, euphoria, immersive experiences, dissociation and non-responsiveness, sensual/erotic enhancement, to dysphoria, fear, terror, and panic.
5-MeO-DMT is being developed and evaluated for potential therapeutic effects in patients with Treatment-Resistant Depression (TRD). Biopharmaceutical company GH Research has sponsored a completed phase 1 study in healthy volunteers and phase 1/2 study in TRD patients where 87.5% of patients with TRD were brought into remission on day 7 in the phase 2 part of the study.
GH Research is currently planning a phase 2b study in TRD patients and have received approval for studies in patients with bipolar II disorder and a current depressive episode and patients with postpartum depression.
Beckley Psytech in collaboration with King’s College London research the safety and tolerability of intranasal 5-MeO-DMT in healthy subjects, in a phase 1 study.
Beckley Psytech CEO Cosmo Feilding-Mellen sees a potential in the short-acting nature of 5-MeO-DMT compared to psilocybin: “Requiring one or two therapists to sit in a room with a single patient for the entire duration of an MDMA or psilocybin experience, which is essentially a whole working day, is probably going to be very resource-intensive and expensive.
There is already a global shortage of psychotherapists, and this poses a potential bottleneck to patiet access in the future.”
5 MeO DMT appears to be similarly effective. A scientific survey published in The Journal of Psychopharmacology found that,
“those who reported being diagnosed with psychiatric disorders, the majority reported improvements in symptoms following 5-MeO-DMT use, including improvements related to post-traumatic stress disorder (79%), depression (77%), anxiety (69%), and alcoholism (66%) or drug use disorder (60%).”
So far research is suggesting both DMT and 5 MeO DMT could help with multiple mental health conditions. Now let’s take a closer look at the three main differences in effects between DMT and 5 MeO DMT.